Ehrlichia ruminantium 

Genome sequence database

Contents of the site:
  • The organism
  • Features of the genome
  • Map of the genome
  • The annotated sequence
  • Complete list of genes
  • The repeats
  • Evolution of new genes
  • Metabolic overview
  • Heartwater - the disease
  • Materials and methods
  • Institutes
  • Personnel
  • History of the project
  • Acknowledgements
  • Ehrlichia ruminantium  is an obligate intracellular bacterium which is carried by ticks of the genus Amblyomma. It infects ruminants throughout sub-Saharan Africa, and in parts of the Caribbean, and causes a rapidly fatal disease known as heartwater.

    Heartwater leads to serious economic losses wherever it is endemic, and there is no effective vaccine against the disease. We sequenced the genome of the organism in order to facilitate a search for genes which will be suitable for incorporation into a recombinant vaccine.

    The circular genome is 1,516,355 bp in length and codes for 888 proteins and 41 stable RNA species. Only 62% of the genome is predicted to be coding sequence, and there are many tandemly repeated and duplicated sequences, some of continuously variable copy number. The repeats appear to be contributing to ongoing evolution of the genome by generating new genes.

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